zinbwave

DOI: 10.18129/B9.bioc.zinbwave  

Zero-Inflated Negative Binomial Model for RNA-Seq Data

Bioconductor version: Release (3.16)

Implements a general and flexible zero-inflated negative binomial model that can be used to provide a low-dimensional representations of single-cell RNA-seq data. The model accounts for zero inflation (dropouts), over-dispersion, and the count nature of the data. The model also accounts for the difference in library sizes and optionally for batch effects and/or other covariates, avoiding the need for pre-normalize the data.

Author: Davide Risso [aut, cre, cph], Svetlana Gribkova [aut], Fanny Perraudeau [aut], Jean-Philippe Vert [aut], Clara Bagatin [aut]

Maintainer: Davide Risso <risso.davide at gmail.com>

Citation (from within R, enter citation("zinbwave")):

Installation

To install this package, start R (version "4.2") and enter:

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("zinbwave")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("zinbwave")

 

HTML R Script zinbwave Vignette
PDF   Reference Manual
Text   NEWS

Details

biocViews DimensionReduction, GeneExpression, ImmunoOncology, RNASeq, Sequencing, SingleCell, Software, Transcriptomics
Version 1.20.0
In Bioconductor since BioC 3.6 (R-3.4) (5.5 years)
License Artistic-2.0
Depends R (>= 3.4), methods, SummarizedExperiment, SingleCellExperiment
Imports BiocParallel, softImpute, stats, genefilter, edgeR, Matrix
LinkingTo
Suggests knitr, rmarkdown, testthat, matrixStats, magrittr, scRNAseq, ggplot2, biomaRt, BiocStyle, Rtsne, DESeq2
SystemRequirements
Enhances
URL
BugReports https://github.com/drisso/zinbwave/issues
Depends On Me
Imports Me benchdamic, clusterExperiment, scBFA, singleCellTK
Suggests Me MAST, splatter
Links To Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package zinbwave_1.20.0.tar.gz
Windows Binary zinbwave_1.20.0.zip
macOS Binary (x86_64) zinbwave_1.20.0.tgz
macOS Binary (arm64) zinbwave_1.20.0.tgz
Source Repository git clone https://git.bioconductor.org/packages/zinbwave
Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/zinbwave
Bioc Package Browser https://code.bioconductor.org/browse/zinbwave/
Package Short Url https://bioconductor.org/packages/zinbwave/
Package Downloads Report Download Stats

Documentation »

Bioconductor

R / CRAN packages and documentation

Support »

Please read the posting guide. Post questions about Bioconductor to one of the following locations: