To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("EMDomics")

In most cases, you don't need to download the package archive at all.

EMDomics

   

This package is for version 3.1 of Bioconductor; for the stable, up-to-date release version, see EMDomics.

Earth Mover's Distance for Differential Analysis of Genomics Data

Bioconductor version: 3.1

The EMDomics algorithm is used to perform a supervised two-class analysis to measure the magnitude and statistical significance of observed continuous genomics data between two groups. Usually the data will be gene expression values from array-based or sequence-based experiments, but data from other types of experiments can also be analyzed (e.g. copy number variation). Traditional methods like Significance Analysis of Microarrays (SAM) and Linear Models for Microarray Data (LIMMA) use significance tests based on summary statistics (mean and standard deviation) of the two distributions. This approach lacks power to identify expression differences between groups that show high levels of intra-group heterogeneity. The Earth Mover's Distance (EMD) algorithm instead computes the "work" needed to transform one distribution into the other, thus providing a metric of the overall difference in shape between two distributions. Permutation of sample labels is used to generate q-values for the observed EMD scores.

Author: Daniel Schmolze [aut, cre], Andrew Beck [aut], Sheida Nabavi [aut]

Maintainer: Daniel Schmolze <emd at schmolze.com>

Citation (from within R, enter citation("EMDomics")):

Installation

To install this package, start R and enter:

## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("EMDomics")

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("EMDomics")

 

HTML R Script EMDomics Vignette
PDF   Reference Manual
Text   NEWS
Text   LICENSE

Details

biocViews DifferentialExpression, GeneExpression, Microarray, Software
Version 1.0.0
In Bioconductor since BioC 3.1 (R-3.2) (1 year)
License MIT + file LICENSE
Depends R (>= 3.2.0)
Imports emdist, BiocParallel, matrixStats, ggplot2
LinkingTo
Suggests knitr
SystemRequirements
Enhances
URL
Depends On Me
Imports Me
Suggests Me
Build Report  

Package Archives

Follow Installation instructions to use this package in your R session.

Package Source EMDomics_1.0.0.tar.gz
Windows Binary EMDomics_1.0.0.zip
Mac OS X 10.6 (Snow Leopard) EMDomics_1.0.0.tgz
Mac OS X 10.9 (Mavericks) EMDomics_1.0.0.tgz
Subversion source (username/password: readonly)
Git source https://github.com/Bioconductor-mirror/EMDomics/tree/release-3.1
Package Short Url http://bioconductor.org/packages/EMDomics/
Package Downloads Report Download Stats

Documentation »

Bioconductor

R / CRAN packages and documentation

Support »

Please read the posting guide. Post questions about Bioconductor to one of the following locations:

Fred Hutchinson Cancer Research Center